Research Project LaCE

Languages for Cell Biological Systems in ELAINE



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15.08.2017 until 30.06.2021

Prof. Dr. Adelinde M. Uhrmacher

M.Sc. Kai Budde,
M.Sc. Philipp Henning, M.Sc. Tom Warnke

Elisa Krummrich, Alina Schubert

DFG  (DFG GEPRIS Link)

Abstract


The research focuses on domain-specific languages for developing spatio-temporal, multi-scale, multi-level, bio-chemical models and their application to study the impact of external electric fields on cell functions such as differentiation.

As part of the collaborative research center 'ELAINE' (electrically active implants) we will use computer-based simulation models to study cellular responses to external electric fields. These simulation studies shall be executed and related to each other across multiple spatial and temporal scales. In order to facilitate the process of conducting and relating simulation studies to each other, we will develop, refine, and apply domain-specific languages for describing models and simulation experiments.

One simulation study is dedicated to cellular mechanisms close to the membrane. Another study is focusing on central intra- and intercellular dynamics, such as the Wnt signaling pathway. Both studies will explore the impact of electric fields on cellular functions such as migration and differentiation.  The project will be executed in close cooperation with other ELAINE projects (e.g. A02, A03, C01 and C04).