Research Project LaCE

Languages for Cell Biological Systems in ELAINE



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15.08.2017 until 30.06.2021

Prof. Dr. Adelinde M. Uhrmacher

M.Sc. Kai Budde

DFG  (DFG GEPRIS Link)

Abstract


The research focuses on domain-specific languages for developing multi-scale, spatio-temporal, bio-chemical models and their application.

As part of the collaborative research center 'ELAINE' (electrically active implants) we will study cellular responses to external electrical fields. Therefore, simulation studies across multiple spatial and temporal scales shall be executed, and related to each other. The application, refinement, and development of domain specific languages for modeling and for simulation experiments will facilitate conducting and relating those simulation studies. One simulation study is dedicated to cellular mechanisms close to the membrane. Another study is focusing on central intra- and inter-cellular dynamics, such as the Wnt signaling pathway. Both studies will explore the impact of electrical fields on cellular functions like migration or differentiation. The project will be executed in close cooperation with other ELAINE projects, e.g. A02, A03, C01 and C04.