01.07.2021 until 30.06.2025
Prof. Dr. Adelinde M. Uhrmacher
Dr. Fiete Haack, M.Sc. Kai Budde (bis 31.05.2022)
This project deals with the application of domain-specific languages for the description of biochemical, spatially and temporally resolved, multiscale and multilevel models. The aim is to investigate the impact of electric fields on cells and cell functions, e.g. with respect to differentiation.
As part of the collaborative research center 'ELAINE' (electrically active implants) we use computer-based simulation models to study cellular responses to external electric fields. These simulation studies shall be executed and related to each other across multiple spatial and temporal scales. To facilitate the process of conducting and relating simulation studies to each other, we have develop, refined, and applied domain-specific languages for describing models and simulation experiments in project A01 (LaCE). Based on this work, this follow-up project will increasingly focus on simulation studies analyzing the influence of electric fields on cell functions, such as signal transduction, differentiation, proliferation and cell communication.
We consider mechanisms at the cell membrane as well as intra- and intercellular processes in bone, cartilage and brain cells that induce cell type specific growth and differentiation mechanisms. The project is carried out in close collaboration with other subprojects of the CRC ( A02, A03, C02, C03 and C04).